Author(s):
Pankaj Prabhakar Dhone, Anjali Wankhade, Vivek Paithankar, J.V. Vyas
Email(s):
pankajdhone4139@gmail.com
DOI:
10.52711/2321-5836.2026.00045 
Address:
Pankaj Prabhakar Dhone*, Anjali Wankhade, Vivek Paithankar, J.V. Vyas
Department of Pharmacology, Vidyabharti College of Pharmacy, Amravati 444-601 Maharashtra India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 4,
Year - 2026
ABSTRACT:
Cognitive impairment and anxiety are common neurological manifestations associated with unhealthy dietary habits, particularly excessive consumption of high salt and high cholesterol diets. Chronic exposure to such diets has been reported to impair learning, memory, and emotional behavior through mechanisms involving oxidative stress, vascular dysfunction, and neuroinflammatory changes. The present study aimed to evaluate the effect of hydroalcoholic extract of Cayratia trifolia leaves (HAECT) on cognitive performance and anxiety-like behavior in high salt and high cholesterol (HS+HC) diet-induced experimental mice. Animals were exposed to HS+HC diet and subsequently treated with HAECT at selected dose levels. Cognitive function was assessed using the Morris Water Maze (MWM), while anxiety-related behavior was evaluated using the Elevated Plus Maze (EPM). In the MWM test, HS+HC diet-fed animals exhibited impaired spatial learning and memory, as evidenced by increased escape latency and reduced retention performance. Treatment with HAECT significantly improved learning and memory parameters compared with disease control animals. In the EPM test, HAECT-treated animals showed increased open-arm exploration and time spent in open arms, indicating reduced anxiety-like behavior. The behavioral improvements observed in treated groups suggest that Cayratia trifolia possesses protective effects against diet-induced cognitive and emotional disturbances. The findings support the potential role of Cayratia trifolia as a natural therapeutic candidate for the management of cognitive dysfunction and anxiety associated with dietary and metabolic disturbances. Further studies are warranted to elucidate the underlying molecular mechanisms responsible for these effects.
Cite this article:
Pankaj Prabhakar Dhone, Anjali Wankhade, Vivek Paithankar, J.V. Vyas. Behavioural Evaluation of Cayratia trifolia in High Salt and High Cholesterol Diet-Induced Cognitive Impairment and Anxiety-Like Deficits in Mice. Research Journal of Pharmacology and Pharmacodynamics. 2026;18(4):335-0. doi: 10.52711/2321-5836.2026.00045
Cite(Electronic):
Pankaj Prabhakar Dhone, Anjali Wankhade, Vivek Paithankar, J.V. Vyas. Behavioural Evaluation of Cayratia trifolia in High Salt and High Cholesterol Diet-Induced Cognitive Impairment and Anxiety-Like Deficits in Mice. Research Journal of Pharmacology and Pharmacodynamics. 2026;18(4):335-0. doi: 10.52711/2321-5836.2026.00045 Available on: https://www.rjppd.org/AbstractView.aspx?PID=2026-18-4-1
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