Author(s):
D. Sunitha, K. Pravalika, B. Bhavani, M Sudhakar
Email(s):
basasunitha@gmail.com , chmrcp@gmail.com
DOI:
10.52711/2321-5836.2026.00020 
Address:
D. Sunitha1*, K. Pravalika2, B. Bhavani3, M Sudhakar4
1Department of Pharmaceutical Chemistry, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Telangana, Osmania University, India.
2,3Department of Pharmacology, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Telangana, India.
4Department of Pharmaceutics, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Telangana, India.
*Corresponding Author
Published In:
Volume - 18,
Issue - 2,
Year - 2026
ABSTRACT:
Toxicodendron succedaneum (L.) Kuntze (synonym: Rhus succedanea L.) is a tree in the family of Anacardiaceae. T. succedaneum has been using to treat diarrhoea, nose and gum bleedings, vomiting, dysentery, cough, tuberculosis, fever, asthma, liver ailments, and ear infections in traditional medicines. Phytochemicals such as agathis flavone, rhus flavone, robusta flavone, succedanea flavanone, and volkensi flavone were isolated from this plant species. Various parts of T. succedaneum disclosed such as antibacterial, anticancer, anti-diabetic, anti-inflammatory, antioxidant, and antiviral activities. Anticancer, antioxidant, and antiviral compounds have been identified from this plant species. Further bioactivity and phytochemical studies should make it possible to obtain additional scientific evidence. Based on the presence of the various chemical constituent’s antidepressant activity was performed using aqueous and alcoholic leaves extract.
Cite this article:
D. Sunitha, K. Pravalika, B. Bhavani, M Sudhakar. Antidepressant Activity of Toxicodendron succedaneum (l) Kuntze Leaves Extract. Research Journal of Pharmacology and Pharmacodynamics.2026;18(2):147-1. doi: 10.52711/2321-5836.2026.00020
Cite(Electronic):
D. Sunitha, K. Pravalika, B. Bhavani, M Sudhakar. Antidepressant Activity of Toxicodendron succedaneum (l) Kuntze Leaves Extract. Research Journal of Pharmacology and Pharmacodynamics.2026;18(2):147-1. doi: 10.52711/2321-5836.2026.00020 Available on: https://www.rjppd.org/AbstractView.aspx?PID=2026-18-2-5
REFERENCES:
1. Sofowora, A., Medicinal Plants and Traditional Medicine in Africa, John Wiley and Sons Ltd., Chichester. New York. Toronto. Singapore, 1982 pages 6,10,11,74,114,256.
2. Gulzar, Salman, M. A. Khan, and Xiaojing Liu. Seed germination strategies of Toxicodendron succedaneum: a fodder crop for saline soils. Rangeland Ecology & Management. 2007: 60(4); 401-407.
3. Farnsworth, N.R., Akerele, O., Medicinal plants in therapy. Bull. World Health. Org.1985: 63(6); 965-981.
4. Kumar, K. Ashok, et al. Chemical composition and antimicrobial activity of the essential oil of Toxicodendron succedaneum Linn. International Journal of Phytomedicine. 2011; 2(4).
5. Ghimire, Kedar Nath. Adsorption of Cd (II), Cu (II), and Zn (II) from aqueous solution onto nitrogen-functionalized Toxicodendron succedaneum. Journal of Chemistry. 2013: 1-7.
6. C. P. Khare. Rhus succedanea Linn. in Indian Medicinal Plants: An Illustrated Dictionary, New York, NY: Springer, 2007, 1-1.
7. S. K. Bhattacharjee, Handbook of Medicinal Plants, Vol. 1. Jaipur: Pointer Publishers, 2004.
8. A. V. S. Kottakkal, Indian Medicinal Plants. Andhra Pradesh: Orient Longman Ltd., 1995.
9. M. Ortiz et al., World Congress Integrative Medicine and Health 2017: part three, BMC Complement. Altern Med. 2017; 17(1): 333.
10. Sathasivampillai SV, Rajamanoharan PRS, Munday M, and Heinrich M. Plants used to treat diabetes in Sri Lankan Siddha Medicine – An ethno pharmacological review of historical and modern sources. J Ethnopharmacol, 2017; 198: 531–599.
11. Dhingra, Dinesh, and Amandeep S. Antidepressant-like activity of Glycyrrhiza glabra L. in mouse models of immobility tests. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2006; 30(3): 449-454.
12. Bach-Rojecky, Lidija, Z. Kalodjera, Samarzija I. The antidepressant activity of Hypericum perforatum L. measured by two experimental methods on mice. Acta Pharmaceutica-Zagreb. 2004; 54(2): 157-162.
13. Machado, Daniele G., et al. Antidepressant-like effect of the extract from leaves of Schinusmolle in mice: Evidence for the involvement of the monoaminergic system. Progress in Neuro-Psychopharmacology and Biological Psychiatry. 2007; 31(2): 421-428.
14. Mora, S., et al. The hydroalcoholic extract of Salvia elegans induces anxiolytic-and antidepressant-like effects in rats. Journal of Ethnopharmacology. 2006; 106(1): 76-81.
15. Kim, Sun-Hee, et al. Antidepressant effect of Chaihu-Shugan-San extract and its constituents in rat models of depression. Life Sciences. 2005; 76(11): 1297-1306
16. Oshima, Yoshiteru, S. Matsuoka, and Ya Ohizumi. Antidepressant principles of Valeriana fauriei roots. Chemical and Pharmaceutical Bulletin. 1995; 43(1): 169-170.
17. Wang, Yang, et al. Antidepressant properties of bioactive fractions from the extract of Crocus sativus L. Journal of Natural Medicines. 2010; 64(1): 24- 30.
18. Rahul J, Mukund T, Aparna K. Evaluation of Antidepressant activity of Tricholepis glaberrima DC using various Paradigms. Research Journal of Pharmacy and Technology. 2022; 15(12): 5610-6. doi: 10.52711/0974-360X.2022.00947.
19. Shruti Mittal, Prashant Gupta, Vijay Nigam. Evaluation of Antidepressant-like Effect of Clitoria ternatea Linn. Research Journal of Pharmacy and Technology. 2021; 14(12): 6437-1. doi: 10.52711/0974-360X.2021.01113.
20. Salman Kapadia, Vanita Kanase. Evaluation of Antidepressant Activity of Ethanolic Extract of Cissus quadrangularis on Swiss Albino Mice. Research Journal of Pharmacy and Technology. 2021; 14(8): 4197-2. doi: 10.52711/0974-360X.2021.00727.
21. R. S. Adnaik, P. S. Gavarkar, S. K. Mohite, C, S Magdum. Anti-Depressant Activity of Ethanolic Extract of Citrullus vulgaris Seeds in Experimentally Induced Depressed Mice. Research J. Pharm. and Tech. 2014; 7(6): 660-662.
22. Rajesh A, Saravanan V, Rajamanoharan RS, Sujarajini V. Bioactivities of Toxicodendron succedaneum (L.) Kuntze Extracts and Isolated Compounds. Anatolian Journal of Biology. 2020; 2: 69-73.